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portrait of Dr Edward Purssell

Dr Edward Purssell

Senior Lecturer

School of Health Sciences, Division of Nursing

Contact Information


Visit Edward Purssell

MG22 DESK 80, Myddelton Street Building

Postal Address

City, University of London
Northampton Square
United Kingdom



Edward is a paediatric nurse specialising in paediatric medicine, infectious diseases and the treatment of fever and febrile illness. His main methodological interests are meta-analysis and the use of Bayesian methods; and he has experience in the use of the R language.

He joined City in 2018 after working as a Senior Lecturer at King's College London, where he helped to establish and run the PG Diploma in Nursing programme. He has been a member of the College Research Ethics Committee, and a NICE Guideline Development Group. He is on the NICE Register of Clinical Experts.


  1. PhD, King's College London, United Kingdom
  2. MSc Microbiology, Birkbeck College, University of London, United Kingdom
  3. Fellow, Higher Education Academy, United Kingdom
  4. Registered Nurse (adult and child), Nursing and Midwifery Council


  1. Senior Lecturer, City, University of London, Oct 2018 – present
  2. Lecturer/Senior Lecturer, King's College London, Apr 1999 – Sep 2018

Memberships of committees

  1. Member: Expert Adviser Panel for the NICE Centre for Guidelines


Conference papers and proceedings (6)

  1. Aitken, L., Kydonaki, K., Blackwood, B., Trahair, L.G., Purssell, E., Sekhon, M. … Walsh, T. (2020). The inconsistent relationship between depth of sedation and outcome: a systematic review and meta-analysis.
  2. Peven, K., Bick, D., Purssell, E., Mallick, L. and Taylor, C. (2019). Provider training and implementation of newborn care interventions at facilities in Malawi: a secondary analysis of Service Provision Assessment survey data.
  3. Harris, J., Armes, J., Ream, E., Purssell, E. and Cornelius, V. (2018). Lesson learnt in developing predictive risk models in psychosocial-oncology: from evidence to implementation.
  4. Harris, J., Cornelius, V., Purssell, E., Ream, E. and Armes, J. (2018). A systematic review to identify risk factors for anxiety after treatment for non-metastatic breast cancer and evaluate multivariate model development.
  5. Sturt, J., Dennick, K., Hestler, D., Hunter, B.M., Oliver, J., Purssell, E. … Fisher, L. (2015). High rates of elevated diabetes distress in research populations: a systematic review and meta-analysis.
  6. Waters, A. and Purssell, E. (2013). The importance attributed to religious belief plays an important role in the attitude of UK nurses towards people with HIV.

Journal articles (88)

  1. Harris, J., Purssell, E., Cornelius, V., Ream, E., Jones, A. and Armes, J. (2020). Development and internal validation of a predictive risk model for anxiety after completion of treatment for early stage breast cancer. Journal of Patient-Reported Outcomes, 4(1). doi:10.1186/s41687-020-00267-w.
  2. Harris, J., Purssell, E., Ream, E., Jones, A., Armes, J. and Cornelius, V. (2020). How to Develop Statistical Predictive Risk Models in Oncology Nursing to Enhance Psychosocial and Supportive Care. Seminars in Oncology Nursing, 36(6). doi:10.1016/j.soncn.2020.151089.
  3. Peven, K., Bick, D., Purssell, E., Rotevatn, T.A., Nielsen, J.H. and Taylor, C. (2020). Evaluating implementation strategies for essential newborn care interventions in low- and low middle-income countries: a systematic review. Health policy and planning, 35(2). doi:10.1093/heapol/czaa122.
  4. Purssell, E., Drey, N., Chudleigh, J., Creedon, S. and Gould, D.J. (2020). The Hawthorne effect on adherence to hand hygiene in patient care. Journal of Hospital Infection, 106(2), pp. 311–317. doi:10.1016/j.jhin.2020.07.028.
  5. Drey, N., Gould, D., Purssell, E., Chudleigh, J., Moralejo, D., Gallagher, R. … Pittet, D. (2020). Applying thematic synthesis to interpretation and commentary in epidemiological studies: Identifying what contributes to successful interventions to promote hand hygiene in patient care. BMJ Quality and Safety, 29(9), pp. 756–763. doi:10.1136/bmjqs-2019-009833.
  6. Gould, D., Lindström, H., Purssell, E. and Wigglesworth, N. (2020). Electronic hand hygiene monitoring: accuracy, impact on the Hawthorne effect and efficiency. Journal of Infection Prevention, 21(4), pp. 136–143. doi:10.1177/1757177420907999.
  7. Gould, D.J., McKnight, J., Leaver, M., Keene, C., Gaze, S. and Purssell, E. (2020). Qualitative interview study exploring frontline managers’ contributions to hand hygiene standards and audit: Local knowledge can inform practice. American Journal of Infection Control, 48(5), pp. 480–484. doi:10.1016/j.ajic.2020.02.005.
  8. Purssell, E. (2020). Can the Critical Appraisal Skills Programme check-lists be used alongside Grading of Recommendations Assessment, Development and Evaluation to improve transparency and decision-making? Journal of Advanced Nursing, 76(4), pp. 1082–1089. doi:10.1111/jan.14303.
  9. Peven, K., Purssell, E., Taylor, C., Bick, D. and Lopez, V.K. (2020). Breastfeeding support in low and middle-income countries: Secondary analysis of national survey data. Midwifery, 82. doi:10.1016/j.midw.2019.102601.
  10. Purssell, E., Gould, D. and Chudleigh, J. (2020). Impact of isolation on hospitalised patients who are infectious: Systematic review with meta-analysis. BMJ Open, 10(2). doi:10.1136/bmjopen-2019-030371.
  11. Gould, D., Chudleigh, J., Purssell, E., Drey, N. and Hawker, C. (2020). Reply to the Letter to the Editor regarding “Survey to explore understanding of the principles of aseptic technique: qualitative content analysis with descriptive analysis of confidence and training”. American Journal of Infection Control, 48(2), pp. 234–235. doi:10.1016/j.ajic.2019.10.015.
  12. Walsh, H., McNeill, A., Purssell, E. and Duaso, M. (2020). A systematic review and Bayesian meta‐analysis of interventions which target or assess co‐use of tobacco and cannabis in single or multi‐substance interventions. Addiction. doi:10.1111/add.14993.
  13. Frood, S. and Purssell, E. (2020). “Barriers to” and “Recommendations for” providing care and support for children living as AIDS orphans in township communities in the Eastern Cape South Africa: A cluster analysis. International Journal of Africa Nursing Sciences, 13. doi:10.1016/j.ijans.2020.100210.
  14. Morley, J., Grocott, P., Purssell, E. and Murrells, T. (2019). Electrochemotherapy for the palliative management of cutaneous metastases: A systematic review and meta-analysis. European Journal of Surgical Oncology, 45(12), pp. 2257–2267. doi:10.1016/j.ejso.2019.07.003.
  15. Xyrichis, A., Fletcher, S., Brearley, S., Philippou, J., Purssell, E., Terblanche, M. … Reeves, S. (2019). Interventions to promote patients and families' involvement in adult intensive care settings: A protocol for a mixed-method systematic review. Systematic Reviews, 8(1). doi:10.1186/s13643-019-1102-9.
  16. Purssell, E. (2019). Using GRADE to reduce the theory-practice gap. Nurse Education Today, 74, pp. 82–84. doi:10.1016/j.nedt.2018.12.008.
  17. McCrae, N. and Purssell, E. (2018). Response to “Calling for a Shared Understanding of Sampling Terminology in Qualitative Research: Proposed Clarifications Derived From Critical Analysis of a Methods Overview by McCrae and Purssell” by Stephen Gentles and Silvia Vilches (International Journal of Qualitative Research, 2017). International Journal of Qualitative Methods, 17(1). doi:10.1177/1609406918804684.
  18. Gould, D.J., Drey, N.S., Chudleigh, J., King, M.F., Wigglesworth, N. and Purssell, E. (2018). Isolating infectious patients: organizational, clinical, and ethical issues. American Journal of Infection Control, 46(8). doi:10.1016/j.ajic.2018.05.024.
  19. Gould, D.J., Chudleigh, J., Purssell, E., Hawker, C., Gaze, S., James, D. … Drey, N. (2018). Survey to explore understanding of the principles of aseptic technique: Qualitative content analysis with descriptive analysis of confidence and training. American Journal of Infection Control, 46(4), pp. 393–396. doi:10.1016/j.ajic.2017.10.008.
  20. Gould, D.J., Navaïe, D., Purssell, E., Drey, N.S. and Creedon, S. (2018). Changing the paradigm: messages for hand hygiene education and audit from cluster analysis. Journal of Hospital Infection, 98(4), pp. 345–351. doi:10.1016/j.jhin.2017.07.026.
  21. Mansell, R. and Purssell, E. (2018). Treatment abandonment in children with cancer in Sub-Saharan Africa: Systematic literature review and meta-analysis. Journal of Advanced Nursing, 74(4), pp. 800–808. doi:10.1111/jan.13476.
  22. Nissen, S., Purssell, E., Shaw, K., Bailey, C., Efstathiou, N. and Dunford, C. (2018). Impaired mobility associated with an increased likelihood of death in children: A systematic review. Journal of Child Health Care, 22(1), pp. 147–158. doi:10.1177/1367493517732839.
  23. Bertille, N., Purssell, E., Hjelm, N., Bilenko, N., Chiappini, E., de Bont, E.G.P.M. … Chalumeau, M. (2018). Symptomatic management of febrile illnesses in children: A systematic review and meta-analysis of parents' knowledge and behaviors and their evolution over time. Frontiers in Pediatrics, 6. doi:10.3389/fped.2018.00279.
  24. Burgess, A. and Purssell, E. (2017). What is the relationship between increased access to HAART, relationship status and fertility decisions amongst HIV-positive women? A literature review and meta-analysis. Journal of Clinical Nursing, 26(23-24), pp. 3800–3810. doi:10.1111/jocn.13731.
  25. McCrae, N., Gettings, S. and Purssell, E. (2017). Social Media and Depressive Symptoms in Childhood and Adolescence: A Systematic Review. Adolescent Research Review, 2(4), pp. 315–330. doi:10.1007/s40894-017-0053-4.
  26. Purssell, E. (2017). Preventing infection in intravenous catheters in the community. British Journal of Community Nursing, 22(8), pp. 374–377. doi:10.12968/bjcn.2017.22.8.374.
  27. Pettit, S., Cresta, E., Winkley, K., Purssell, E. and Armes, J. (2017). Glycaemic control in people with type 2 diabetes mellitus during and after cancer treatment: A systematic review and metaanalysis. PLoS ONE, 12(5). doi:10.1371/journal.pone.0176941.
  28. Duaso, M.J., Bakhshi, S., Mujika, A., Purssell, E. and While, A.E. (2017). Nurses’ smoking habits and their professional smoking cessation practices. A systematic review and meta-analysis. International Journal of Nursing Studies, 67, pp. 3–11. doi:10.1016/j.ijnurstu.2016.10.011.
  29. McCrae, N. and Purssell, E. (2016). Is it really theoretical? A review of sampling in grounded theory studies in nursing journals. Journal of Advanced Nursing, 72(10), pp. 2284–2293. doi:10.1111/jan.12986.
  30. Bertille, N., Purssell, E., Corrard, F., Chiappini, E. and Chalumeau, M. (2016). Fever phobia 35 years later: Did we fail? Acta Paediatrica, International Journal of Paediatrics, 105(1), pp. 9–10. doi:10.1111/apa.13221.
  31. McCrae, N. and Purssell, E. (2015). Eligibility criteria in systematic reviews published in prominent medical journals: A methodological review. Journal of Evaluation in Clinical Practice, 21(6), pp. 1052–1058. doi:10.1111/jep.12448.
  32. Sampat, B. and Purssell, E. (2015). Routine screening of women having caesarean section for MRSA: Ritual or rational? British Journal of Midwifery, 23(8), pp. 560–564. doi:10.12968/bjom.2015.23.8.560.
  33. Purssell, E. and Collin, J. (2015). Fever phobia: The impact of time and mortality – A systematic review and meta-analysis. International Journal of Nursing Studies, 56, pp. 81–89. doi:10.1016/j.ijnurstu.2015.11.001.
  34. Richardson, M. and Purssell, E. (2015). Who's afraid of fever? Archives of Disease in Childhood, 100(9), pp. 818–820. doi:10.1136/archdischild-2014-307483.
  35. McCrae, N., Blackstock, M. and Purssell, E. (2015). Eligibility criteria in systematic reviews: A methodological review. International Journal of Nursing Studies, 52(7), pp. 1269–1276. doi:10.1016/j.ijnurstu.2015.02.002.
  36. Purssell, E. (2015). Reviewing the importance of the cold chain in the distribution of vaccines. British Journal of Community Nursing, 20(10), pp. 481–486. doi:10.12968/bjcn.2015.20.10.481.
  37. Purssell, E. (2014). Shingles vaccination: Background and advice for community nurses. British Journal of Community Nursing, 19(9), pp. 442–446. doi:10.12968/bjcn.2014.19.9.442.
  38. Akpaloo, W. and Purssell, E. (2014). Does the use of dihydroartemisinin-piperaquine in treating patients with uncomplicated falciparum malaria reduce the risk for recurrent new falciparum infection more than artemether-lumefantrine? Malaria Research and Treatment, 2014. doi:10.1155/2014/263674.
  39. Purssell, E. (2014). Cyclooxygenase inhibitors inhibit antibody response through interference with MAPK/ERK pathways and BLIMP-1 inhibition. Medical Hypotheses, 83(3), pp. 372–377. doi:10.1016/j.mehy.2014.06.015.
  40. Duaso, M.J., Mcdermott, M.S., Mujika, A., Purssell, E. and While, A. (2014). Do doctors' smoking habits influence their smoking cessation practices? A systematic review and meta-analysis. Addiction, 109(11), pp. 1811–1823. doi:10.1111/add.12680.
  41. Purssell, E. (2014). Fever in children - A concept analysis. Journal of Clinical Nursing, 23(23-24), pp. 3575–3582. doi:10.1111/jocn.12347.
  42. Purssell, E. and While, A.E. (2014). Czy zastosowanie leków przeciwgora̧czkowych u dzieci z ostrymi zakazeniami wydłuza czas trwania choroby? Przegla̧d systematyczny i metaanaliza. Pediatria Polska, 89(2). doi:10.1016/j.pepo.2014.02.002.
  43. Purssell, E. (2013). Reply. Journal of Pediatrics, 163(6), pp. 1796–1797. doi:10.1016/j.jpeds.2013.09.015.
  44. Purssell, E. and While, A. (2013). Parental self-efficacy and its measurement - an evaluation of a parental self-efficacy measurement scale. Journal of Clinical Nursing, 22(9-10), pp. 1487–1494. doi:10.1111/j.1365-2702.2012.04308.x.
  45. Purssell, E., Fanner, M. and Barnes, A. (2013). Needs and priorities of young people with human immunodeficiency virus. Nursing children and young people, 25(4), pp. 20–24. doi:10.7748/ncyp2013.
  46. Purssell, E. (2013). Antipyretic use in children: More than just temperature. Jornal de Pediatria, 89(1), pp. 1–3. doi:10.1016/j.jped.2013.02.001.
  47. Purssell, E. and While, A.E. (2013). Does the use of antipyretics in children who have acute infections prolong febrile illness? A systematic review and meta-analysis. Journal of Pediatrics, 163(3). doi:10.1016/j.jpeds.2013.03.069.
  48. Purssell, E. (2012). A topic in 10 questions: Gastrointestinal infections from a nutritional perspective. The journal of family health care, 22(1), pp. 28–29.
  49. Purssell, E. (2011). Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone. Archives of Disease in Childhood, 96(12), pp. 1175–1179. doi:10.1136/archdischild-2011-300424.
  50. Purssell, E. and While, A. (2011). P=nothing, or why we should not teach healthcare students about statistics. Nurse Education Today, 31(8), pp. 837–840. doi:10.1016/j.nedt.2010.11.017.
  51. Purssell, E. (2011). Available evidence insufficient to assess safety and effectiveness of flu vaccines for older people. Evidence-Based Nursing, 13(3), pp. 72–72. doi:10.1136/ebn1064.
  52. Purssell, E. and While, A. (2011). Development of a scale to measure parental self-efficacy in the care of pre-school children during periods of health and minor illness: Integrating health and social policy methods. Journal of Clinical Nursing, 20(11-12), pp. 1623–1631. doi:10.1111/j.1365-2702.2010.03591.x.
  53. Purssell, E. and While, A. (2011). Knowledge about pandemic influenza in healthcare and non-healthcare students in London. Health Education Journal, 70(2), pp. 217–224. doi:10.1177/0017896910376228.
  54. Purssell, E. (2010). Available evidence insufficient to assess safety and effectiveness of flu vaccines for older people. Evidence-Based Nursing, 13(3), p. 72. doi:10.1136/ebn.13.3.72.
  55. Purssell, E. (2009). Prevention and management of gastrointestinal infections in infants from a nutritional perspective. The journal of family health care, 19(6), pp. 200–203.
  56. Purssell, E. (2009). Uncertainties and Anxieties about Vaccination, Answering Parent's Concerns. Journal of Pediatric Nursing, 24(5), pp. 433–440. doi:10.1016/j.pedn.2009.03.002.
  57. Purssell, E., While, A. and Coomber, B. (2009). Tympanic thermometry--normal temperature and reliability. Paediatric nursing, 21(6), pp. 40–43.
  58. Purssell, E. (2009). Upper respiratory tract infection in infants from a nutritional perspective. The journal of family health care, 19(5), pp. 164–168.
  59. Purssell, E. (2009). Parental fever phobia and its evolutionary correlates. Journal of Clinical Nursing, 18(2), pp. 210–218. doi:10.1111/j.1365-2702.2007.02077.x.
  60. Purssell, E. (2008). Combining paracetamol and ibuprofen for fever in children. BMJ (Clinical research ed.), 337. doi:10.1136/bmj.a1590.
  61. Purssell, E. (2008). Paracetamol with ibuprofen: Combining paracetamol and ibuprofen for fever in children. BMJ, 337(7670), p. 593.
  62. Purssell, E. (2008). Combining paracetamol and ibuprofen for fever in children. BMJ (Clinical research ed.), 337. doi:10.1136/bmj.a1590.
  63. Purssell, E. (2007). Treatment of fever and over-the-counter medicines. Archives of Disease in Childhood, 92(10), pp. 900–901. doi:10.1136/adc.2007.118810.
  64. Purssell, E. (2007). Commentary on Farnell S, Maxwell L, Tan, S, Rhodes A & Phillips A (2005) Temperature measurement: Comparison of non-invasive methods used in adult critical care. Journal of Clinical Nursing 14, 632-639. Journal of Clinical Nursing, 16(1), pp. 217–219. doi:10.1111/j.1365-2702.2005.01419.x.
  65. Purssell, E. (2006). Response. Journal of Clinical Nursing, 15(12), p. 1595. doi:10.1111/j.1365-2702.2006.01686.x.
  66. Purssell, E. (2005). Symptoms in the host: Infection and treatment model. Journal of Clinical Nursing, 14(5), pp. 555–561. doi:10.1111/j.1365-2702.2004.01109.x.
  67. Purssell, E. (2005). Evolutionary nursing: The case of infectious diseases. Journal of Advanced Nursing, 49(2), pp. 164–172. doi:10.1111/j.1365-2648.2004.03276.x.
  68. Purssell, E. (2004). Fever phobia revisited [2]. Archives of Disease in Childhood, 89(1), pp. 89–90.
  69. Purssell, E. (2004). Exploring the evidence surrounding the debate on MMR and autism. British journal of nursing (Mark Allen Publishing), 13(14), pp. 834–838. doi:10.12968/bjon.2004.13.14.14309.
  70. Purssell, E. (2003). Paediatric Neurosurgery. A Handbook for the Multidisciplinary Team. Journal of Advanced Nursing, 41(3), pp. 314–315. doi:10.1046/j.1365-2648.2003.t01-1-25862.x.
  71. Purssell, E. (2003). Community-acquired MRSA in children. Paediatric nursing, 15(2), pp. 47–51.
  72. Purssell, E. (2002). Commentary: Children infected with meningitis before 1 year of age were at increased risk of disability at 5 years of age. Evidence-Based Nursing, 5(2), p. 59. doi:10.1136/ebn.5.2.59.
  73. Purssell, E. (2002). Treating fever in children: paracetamol or ibuprofen? British journal of community nursing, 7(6), pp. 316–320. doi:10.12968/bjcn.2002.7.6.10477.
  74. Purssell, E. (2002). HIV and breastfeeding feedback. Professional nurse (London, England), 18(2).
  75. Purssell, E. (2001). Antibiotic risk should be emphasised. Professional nurse (London, England), 17(2), p. 92.
  76. Purssell, E. (2001). 20 years of AIDS. Paediatric nursing, 13(6), p. 3. doi:10.7748/paed.13.6.3.s1.
  77. Purssell, E. (2000). Physical treatment of fever. Archives of Disease in Childhood, 82(3), pp. 238–239. doi:10.1136/adc.82.3.238.
  78. Purssell, E. (2000). The use of antipyretic medications in the prevention of febrile convulsions in children. Journal of Clinical Nursing, 9(4), pp. 473–480. doi:10.1046/j.1365-2702.2000.00360.x.
  79. Purssell, E. (1999). Flu is wreaking havoc. Nursing times, 95(2), p. 43.
  80. Purssell, E. (1998). The diagnosis, transmission and prevention of HIV-1 in the infant under 18 months of age: Implications for nursing practice. Journal of Clinical Nursing, 7(4), pp. 297–306. doi:10.1046/j.1365-2702.1998.00236.x.
  81. Purssell, E. (1998). An infection out of season: respiratory syncytial virus. Paediatric nursing, 10(8), pp. 27–28. doi:10.7748/paed.10.8.27.s20.
  82. Purssell, E. (1998). A lack of attention to infection control procedures. Nursing times, 94(40), p. 45.
  83. Purssell, E. and Gould, D. (1997). A common ailment. Nursing times, 93(3), pp. 53–56.
  84. Purssell, E. (1996). Preventing nosocomial infection in paediatric wards. Journal of Clinical Nursing, 5(5), pp. 313–318. doi:10.1111/jocn.1996.5.5.313.
  85. Purssell, E. (1995). LISTENING TO CHILDREN: MEDICAL TREATMENT AND CONSENT. Journal of Advanced Nursing, 21(4), pp. 623–624. doi:10.1046/j.1365-2648.1995.21040623.x.
  86. Purssell, E. (1994). The process of normalisation in children with chronic illness. Paediatric nursing, 6(10), pp. 26–28. doi:10.7748/paed.6.10.26.s28.
  87. Purssell, E. (1994). Telling children about their impending death. British journal of nursing (Mark Allen Publishing), 3(3), pp. 119–120. doi:10.12968/bjon.1994.3.3.119.
  88. Purssell, E., Drey, N., Chudleigh, J., Gould, D., Gallagher, R. and Hawker, C. Survey with content analysis to explore nurses’ satisfaction with opportunities to undertake continuing professional education in relation to aseptic technique. Nurse Education Today.