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  2. 2021
  3. January
  4. Mechanisms underlying learning and training in working memory tasks

Jan

27

Wednesday

Mechanisms underlying learning and training in working memory tasks

1.00pm

Seminars

Public

This event will take place online via Zoom

Speaker: Dr Kyriaki Sidiropoulou

Summary: Working memory (WM) is the ability to hold on-line and manipulate information. The prefrontal cortex (PFC) is a key brain region involved in WM, while the hippocampus is also involved, particularly, in spatial WM. Although several studies have investigated the neuronal substrates of WM in trained animals, the effects and the mechanisms underlying learning WM tasks have not been explored. In this presentation, I will discuss results from our laboratory showing changes in synaptic transmission, synaptic plasticity and dendritic spine density following learning WM tasks. To investigate learning-induced changes, we  train mice in the delayed alternation task for 9 days (adaptive group) and compare this group to either naïve mice (which stayed in their homecage) or mice trained in the alternation procedure only (non-adaptive). Our results show that dendritic spine density in the PFC and the hippocampus are altered in response to training. In addition, synaptic plasticity in the PFC is enhanced while the evoked field excitatory synaptic potential (fEPSP) response is increased in the hippocampus, following learning. Furthermore, synaptic plasticity and dendritic spine density in the PFC correlate with mouse performance in the early training stages of the delayed alternation task. Finally, I will discuss these rodent results translate in humans.

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When and where

1.00pm - 2.00pmWednesday 27th January 2021