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  4. CANCELLED: Understanding why trials in critical care work (or not): the role of process evaluation




CANCELLED: Understanding why trials in critical care work (or not): the role of process evaluation




This event is now cancelled: apologies for any disappointment and inconvenience caused.

The Centre for Health Services Research at the School of Health Science, City, University of London welcomes you to our next research seminar.

In this seminar, Lydia will discuss the role of process evaluation within clinical trials and explain how it can be used evaluate and understand the implementation and delivery of complex interventions. The seminar will explore what is currently known about conducting clinical trials within the ICU; the specific complex challenges of this environment; and why process evaluation is therefore a necessary component. Lydia will present the POETIC framework, which she developed to provide guidance for conducting process evaluations alongside multi-centre randomised trials in UK ICUs. The framework has been used to guide the process evaluations of several complex critical care trials (VAPrapid-2, POPPI, SANDWICH, A2B), and Lydia will use a worked example to demonstrate the importance of process evaluations for adding explanatory power to trial results. She will describe how this can be used to inform future trial conduct, process evaluation methodology, and her current work in the A2B trial.

Presenter: Lydia Emerson

Lydia Emerson is a clinical researcher who joined City, University of London as a research fellow in 2018. She undertook her undergraduate and postgraduate studies at Queen’s University Belfast.
Lydia's research interests focus on clinical trials methodology, and she has a specific interest in process evaluation of complex intervention trials in critical care. Lydia’s PhD focussed on the development and application of a framework for conducting process evaluations within the intensive care unit (ICU) setting. In her current role at City, Lydia is conducting the process evaluation of the A2B trial (Alpha-2 agonists for sedation to produce better outcomes from critical illness). A2B is a large multi-centre randomised trial currently running in over forty UK ICUs.

A light lunch with refreshments will be available 12.30 with the talk starting at 12:45. For further information please contact Verity Sullivan (

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When and where

12.30pm - 2.00pmMonday 16th March 2020

MG26 City, University of London Northampton Square London EC1V 0HB United Kingdom