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Measuring visual field distortions and cortical changes in amblyopia




This event is a Centre for Applied Vision Research Seminar.

Lunch will be provided at 12:00. The seminar will commence at 12:30 with an introduction from Simon Grant at 12:15.


Denis Schluppeck, University of Nottingham

Denis Schluppeck read Natural Sciences at the University of Cambridge (1996) and obtained a DPhil in Neuroscience from the University of Oxford (2001). After post-doctoral appointments in neuroimaging labs in the USA (at UCLA and NYU), he joined the Visual Neuroscience Group / School of Psychology at The University of Nottingham as a RCUK Academic Fellow in 2006. He is now an associate professor in the School and uses a combination of psychophysics and high-field magnetic resonance imaging (MRI) to study how we use our senses of vision and touch to gather information about the world and how we store and use that information to make perceptual decisions. He collaborates closely with colleagues at the Sir Peter Mansfield Imaging Centre at Nottingham.


Abnormal visual experience early in life alters the functional architecture of visual cortex and results in marked deficits in monocular visual acuity and binocular function - collectively referred to as amblyopia. Recently, we have shown there are also idiosyncratic distortions in the visual field representation of amblyopic individuals. Here, we attempt to map the associated changes in early visual cortex of subjects with amblyopia, using high-resolution magnetic resonance imaging (MRI) at 7 T. To measure visual field representations functionally, we used anatomical and functional MRI to obtain retinotopic maps in healthy and amblyopic participants. Stimuli were presented to each eye, monocularly. Outside the scanner, we also assessed fixation stability in each participant. We used the population receptive field (pRF) method to estimate polar angle, eccentricity maps, and pRF sizes. Our results reveal systematic differences in the maps of normal and amblyopic subjects. We relate these changes to behavioural maps measured using a dichoptic positional matching technique and individual anatomy.

Affiliations: David Arnoldussen Zahra Hussain, Rosa Sanchez-Panchuelo, Susan Francis, Ben Webb, Denis Schluppeck, Paul McGraw, Visual Neuroscience Group, Sir Peter Mansfield Imaging Centre, University of Nottingham, UK

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When & where

12.00pm - 2.00pmWednesday 30th September 2015

C310 Tait Building City, University of London Northampton Square London EC1V 0HB United Kingdom