- West, J., Adler, F., Gallaher, J., Strobl, M., Brady-Nicholls, R., Brown, J. … Anderson, A.R.A. (2023). A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation. eLife, 12. doi:10.7554/elife.84263.
- Lemant, J., Le Sueur, C., Manojlović, V. and Noble, R. (2022). Robust, Universal Tree Balance Indices. Systematic Biology, 71(5), pp. 1210–1224. doi:10.1093/sysbio/syac027.
- Noble, R., Burri, D., Le Sueur, C., Lemant, J., Viossat, Y., Kather, J.N. … Beerenwinkel, N. (2021). Spatial structure governs the mode of tumour evolution. Nature Ecology & Evolution, 6(2), pp. 207–217. doi:10.1038/s41559-021-01615-9.
- Mosca, M., Hermange, G., Tisserand, A., Noble, R., Marzac, C., Marty, C. … Plo, I. (2021). Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms. Blood, 138(22), pp. 2231–2243. doi:10.1182/blood.2021010986.
- Kuosmanen, T., Cairns, J., Noble, R., Beerenwinkel, N., Mononen, T. and Mustonen, V. (2021). Drug-induced resistance evolution necessitates less aggressive treatment. PLOS Computational Biology, 17(9). doi:10.1371/journal.pcbi.1009418.
- Noble, R.J., Walther, V., Roumestand, C., Hochberg, M.E., Hibner, U. and Lassus, P. (2021). Paracrine Behaviors Arbitrate Parasite-Like Interactions Between Tumor Subclones. Frontiers in Ecology and Evolution, 9. doi:10.3389/fevo.2021.675638.
- Viossat, Y. and Noble, R. (2021). A theoretical analysis of tumour containment. Nature Ecology & Evolution, 5(6), pp. 826–835. doi:10.1038/s41559-021-01428-w.
- Dujon, A.M., Aktipis, A., Alix‐Panabières, C., Amend, S.R., Boddy, A.M., Brown, J.S. … Ujvari, B. (2021). Identifying key questions in the ecology and evolution of cancer. Evolutionary Applications, 14(4), pp. 877–892. doi:10.1111/eva.13190.
- Noble, R., Burley, J.T., Le Sueur, C. and Hochberg, M.E. (2020). When, why and how tumour clonal diversity predicts survival. Evolutionary Applications, 13(7), pp. 1558–1568. doi:10.1111/eva.13057.
- Bacevic, K., Noble, R., Soffar, A., Wael Ammar, O., Boszonyik, B., Prieto, S. … Fisher, D. (2017). Spatial competition constrains resistance to targeted cancer therapy. Nature Communications, 8(1). doi:10.1038/s41467-017-01516-1.
- Hochberg, M.E. and Noble, R.J. (2017). A framework for how environment contributes to cancer risk. Ecology Letters, 20(2), pp. 117–134. doi:10.1111/ele.12726.
- Vasse, M., Noble, R.J., Akhmetzhanov, A.R., Torres-Barceló, C., Gurney, J., Benateau, S. … Hochberg, M.E. (2017). Antibiotic stress selects against cooperation in the pathogenic bacterium
Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences, 114(3), pp. 546–551. doi:10.1073/pnas.1612522114. - Hochberg, M.E., Noble, R.J. and Braude, S. (2016). A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats. . doi:10.1101/079012.
- Noble, R., Kaltz, O., Nunney, L. and Hochberg, M.E. (2016). Overestimating the role of environment in cancers. Cancer Prevention Research, 9(10), pp. 773–776. doi:10.1158/1940-6207.CAPR-16-0126.
- Noble, R., Kaltz, O. and Hochberg, M.E. (2015). Peto's paradox and human cancers. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1673), pp. 20150104–20150104. doi:10.1098/rstb.2015.0104.
- Noble, R., Kaltz, O. and Hochberg, M.E. (2015). Statistical interpretations and new findings on Variation in Cancer Risk
Among Tissues. . - Noble, R., Christodoulou, Z., Kyes, S., Pinches, R., Newbold, C.I. and Recker, M. (2013). The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria. eLife, 2. doi:10.7554/elife.01074.
- Noble, R. and Recker, M. (2012). A Statistically Rigorous Method for Determining Antigenic Switching Networks. PLoS ONE, 7(6). doi:10.1371/journal.pone.0039335.
- Fastman, Y., Noble, R., Recker, M. and Dzikowski, R. (2012). Erasing the Epigenetic Memory and Beginning to Switch—The Onset of Antigenic Switching of var Genes in Plasmodium falciparum. PLoS ONE, 7(3). doi:10.1371/journal.pone.0034168.
Dr Robert Noble
Contact details
Address
Dr Robert Noble
E231
, Drysdale Building [E]
City, University of London
Northampton Square
London EC1V 0HB
United Kingdom
Northampton Square
London EC1V 0HB
United Kingdom
Personal links
About
Overview
Dr Robert Noble uses mathematical and computational models to investigate the evolution and ecology of cancer, in collaboration with experimental biologists and clinicians.
Dr Noble obtained a DPhil in Zoology from the University of Oxford in 2014, with a thesis on mathematical modelling of infectious disease. He then held postdoctoral research positions in mathematical oncology at the Institut des Sciences de l'Evolution de Montpellier (2014-2017), ETH Zurich (2017-2020), and the University of Zurich (2018-2020). He joined City as a lecturer in July 2020.
Qualifications
- DPhil, University of Oxford, United Kingdom, Oct 2009 – Jan 2014
- MMath, University of York, United Kingdom, Oct 1999 – Jul 2003
Employment
- Lecturer in Applied Mathematics, City, University London, Jul 2020 – present
- Postdoctoral researcher, University of Zurich, May 2018 – Jun 2020
- Postdoctoral researcher, Swiss Federal Institute of Technology in Zurich, Feb 2017 – Jun 2020
- Postdoctoral researcher, Institut des Sciences de l’Evolution de Montpellier, Jan 2014 – Jan 2017
Research students
Kimberley Verity
Attendance: Oct 2022 – Sep 2026, full-time
Thesis title: Mathematical theory of tumour evolutionary modes
Role: 1st Supervisor
Blair Colyer
Attendance: Jul 2021 – Jun 2025, full-time
Thesis title: Mathematical models of cancer adaptive therapy
Role: 1st Supervisor
Further information: Coauthor of "Warlock: an automated computational workflow for simulating spatially structured tumour evolution" arXiv 2301.07808 (2023)
Veselin Manojlovic
Attendance: Sep 2020 – Sep 2024, full-time
Thesis title: Mathematical Classification of the Modes of Tumour Evolution
Role: 1st Supervisor
Further information: Coauthor of "Robust, Universal Tree Balance Indices" Systematic Biology 71;1210–1224 (2022)
Coauthor of "Warlock: an automated computational workflow for simulating spatially structured tumour evolution" arXiv 2301.07808 (2023)
Awarded nine-month Enrichment Scheme placement at the Alan Turing Institute
Publications
Publications by category
Conference papers and proceedings (2)
- Isabelle, P.L.O., Tisserand, A., Noble, R., Dagher, T., Maslah, N., Mosca, M. … Vainchenker, W. (2020). INVESTIGATING THE MECHANISMS OF IFNALPHA THERAPY IN JAK2V617F AND CALR MUTATED MYELOPROLIFERATIVE NEOPLASMS.
- Tisserand, A., Noble, R., Mosca, M., Marzac, C., Vertenoeil, G., Campario, H. … Plo, I. (2019). Predicting the Long-Term Efficacy of Ifnα in JAK2V617F and Calr-Mutated MPN Patients. doi:10.1182/blood-2019-127903