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  1. Alison Binns
People

Contact Information

Contact

Postal Address

City, University of London
Northampton Square
London
EC1V 0HB
United Kingdom

About

Background

Alison became a lecturer in the Division of Optometry and Visual Science at City University London in July 2013. Her specialism is the early detection and treatment of Age-Related Macular Degeneration. Alison gained a degree in Optometry and Vision Sciences at Cardiff University in 1998.

After passing Professional Qualifying Examinations, and working for several years as an Optometrist, she returned to Cardiff University to obtain a PhD investigating the electrophysiological characteristics of early age-related macular degeneration (AMD), and continued to work in the School of Optometry and Vision Sciences from 2004-2013.

For the past 13 years, Alison has been carrying out research into the most sensitive clinical tools for the diagnosis and monitoring of AMD and, more recently, into treatments for early AMD. In July 2013, Alison became a lecturer in the Division of Optometry and Visual Science in City University London, where she continues to carry out both research and teaching roles.

Qualifications

BSc, PhD

Administrative roles/Clinical activity

- Primary Care Clinic Co-ordinator

Memberships of professional bodies

- College of Optometrists
- Registered with the General Optical Council

Languages

Spanish

Research

Research overview

Alison's principal research interest is age-related macular degeneration (AMD). Approximately 500,000 people in the UK have advanced AMD, and it is responsible for more than half of all registrations as sight impaired or severely sight impaired. Her research is targeted at the early stage of AMD, aiming to develop treatments to prevent progression to the sight-threatening form of the disease, and to identify sensitive biomarkers. Alison is also interested in the evaluation of low vision service provision for people with visual impairment, and has conducted two significant systematic reviews in the field. A further area of research interest is the evaluation of retinal adaptation using electrophysiology, psychophysics and imaging techniques. She considers this to be an important area of research, given the sensitivity of measures of retinal adaptation to early stages of retinal disease, including AMD.

Research areas

- Early detection and effective monitoring of age-related macular degeneration (AMD)
- Development of new treatments for early AMD, to prevent onset of visual loss
- Development of clinical tools for the assessment of retinal adaptation
- Evaluation of visual rehabilitation strategies for people with visual impairment
- Electrophysiological biomarkers of retinal and optic nerve disease
- Effect of hypoxia on visual function

Grants

AMD light trial (ALIGHT): an exploratory phase I/IIa clinical trial investigating the effect of low level illumination at night on the progression of AMD. Oxygen consumption of the retina is reduced by exposing the eye to low illumination during sleep, thus minimising retinal hypoxia. This is a collaboration with Cardiff University (Dr Tom Margrain), Bristol Eye Hospital (Miss Clare Bailey), and Polyphotonix Medical Ltd. Funded by the College of Optometrists.

Development of retinal imaging densitometer: The design, development and evaluation of a new retinal imaging densitometer in a collaborative project with Cardiff University and the UK Astronomy and Technology Centre (UKATC). The densitometer measures reflectance of light from the retina to objectively evaluate the recovery of photopigment after exposure to a bright adapting light. The collaboration with UKATC permits the use of 'cutting edge' astronomical imaging technology to generate, for the first time, a topographical map of photopigment regeneration. This project is funded by the NIHR I4I scheme.

Evaluation of functional biomarkers for the early detection and monitoring of autosomal dominant optic atrophy: in collaboration with Professor Marcela Votruba and Dr Tom Margrain at Cardiff University.

Investigation of the effect of hypoxia on retinal function in AMD: Literature suggests that lack of oxygen at the outer retina may be responsible for the functional deficits seen in AMD. However, this hypothesis has never been directly evaluated. The effect of inhalation of supplementary oxygen on a range of visual functions will be investigated, as will the effect of background light level on hypoxia in AMD. This project is supported by the Cardiff University Endowment Scholarship.

Alison has also received grant funding from the Macular Society and the RNIB.

Research centres

- Ophthalmic Public Health

Principal collaborators

- Dr Tom Margrain (Cardiff University)
- Professor Marcela Votruba (Cardiff University)
- Miss Clare Bailey (Bristol Eye Hospital)
- Dr Joan Gispets (University Polytechnica de Catalunia)

Research Students

Name
Chris Jones
Further Information
In collaboration with Dr Tom Margrain at Cardiff University
Name
Claire Mckeague
Further Information
In collaboration with Dr Tom Margrain at Cardiff University
Name
Enyam Morny
Further Information
In collaboration with Dr Tom Margrain at Cardiff University
Name
Miss Angharad Hobby
Thesis Title
Measuring Effects of long term anti-VEGF therapy on peripheral retinal function and structure
Further Information
PhD start date Oct 2014; Second supervisor

Publications

Conference Papers and Proceedings (3)

  1. Taylor, D.J., Smith, N., Binns, A. and Crabb, D. (2016). Searching for objects in everyday scenes and recognising faces: measuring performance in people with dry age-related macular degeneration (AMD). .
  2. Callaghan, T., Binns, A. and Margrain, T. (2016). Functional biomarkers of hypoxia in Age-related macular degeneration. .
  3. Binns, A.M. and Margrain, T.H. (2003). The ERG photostress test. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology May, FT LAUDERDALE, FLORIDA.

Journal Articles (27)

  1. Binns, A. (2016). Effect of a Home Visit-Based Low Vision Rehabilitation Intervention on Visual Function Outcomes. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(15), pp. 6668–6668. doi:10.1167/iovs.16-21126.
  2. Hobby, A.E., Kozareva, D., Yonova, E.H., Hossain, I.T., Katta, M., Huntjens, B., Binns, A., Hammond, C.J. and Mahroo, O.A.R. (2016). Effect of varying skin surface electrode position on electroretinogram responses recorded using a handheld stimulating and recording system. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12) .
  3. Acton, J.H., Molik, B., Binns, A., Court, H. and Margrain, T.H. (2016). Effect of rehabilitation worker input on visual function outcomes in individuals with low vision: Study protocol for a randomised controlled trial. Trials, 17(1) . doi:10.1186/s13063-016-1235-2.
  4. Bi, W., Gillespie-Gallery, H., Binns, A. and Barbur, J.L. (2016). Flicker sensitivity in normal aging—monocular tests of retinal function at photopic and mesopic light levels. Investigative Ophthalmology and Visual Science, 57(2), pp. 387–395. doi:10.1167/iovs.15-16481.
  5. Morny, E.K.A., Margrain, T.H., Binns, A.M. and Votruba, M. (2015). Electrophysiological ON and OFF responses in autosomal dominant optic atrophy. Investigative Ophthalmology and Visual Science, 56(13), pp. 7629–7637. doi:10.1167/iovs.15-17951.
  6. McKeague, C., Margrain, T.H., Bailey, C. and Binns, A.M. (2014). Low-level night-time light therapy for age-related macular degeneration (ALight): !tudy protocol for a randomized controlled trial. Trials, 15(1) . doi:10.1186/1745-6215-15-246.
  7. Gispets, J., Cardona, G., Tomas, N., Fuste, C., Binns, A. and Fortes, M.A. (2014). A New Slit Lamp-Based Technique for Anterior Chamber Angle Estimation. OPTOMETRY AND VISION SCIENCE, 91(6), pp. 668–675.
  8. Wood, A., Margrain, T. and Binns, A.M. (2014). Detection of early age-related macular degeneration using novel functional parameters of the focal cone electroretinogram. PLoS ONE, 9(5) . doi:10.1371/journal.pone.0096742.
  9. Gaffney, A.J., Binns, A.M. and Margrain, T.H. (2014). Measurement of cone dark adaptation: a comparison of four psychophysical methods. Doc Ophthalmol, 128(1), pp. 33–41. doi:10.1007/s10633-013-9418-6.
  10. Gaffney, A.J., Margrain, T.H., Bunce, C.V. and Binns, A.M. (2014). How effective is eccentric viewing training? A systematic literature review. Ophthalmic and Physiological Optics, 34(4), pp. 427–437. doi:10.1111/opo.12132.
  11. McKeague, C., Binns, A.M. and Margrain, T.H. (2014). An evaluation of two candidate functional biomarkers for AMD. Optometry and Vision Science, 91(8), pp. 916–924. doi:10.1097/OPX.0000000000000318.
  12. Gaffney, A.J., Binns, A.M. and Margrain, T.H. (2013). The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration. Doc Ophthalmol, 127(3), pp. 191–199. doi:10.1007/s10633-013-9400-3.
  13. Gaffney, A.J., Binns, A.M. and Margrain, T.H. (2013). The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration. Documenta Ophthalmologica, 127(3), pp. 191–199. doi:10.1007/s10633-013-9400-3.
  14. Gaffney, A.J., Binns, A.M. and Margrain, T.H. (2012). Aging and cone dark adaptation. Optom Vis Sci, 89(8), pp. 1219–1224. doi:10.1097/OPX.0b013e318263c6b1.
  15. Binns, A.M., Bunce, C., Dickinson, C., Harper, R., Tudor-Edwards, R., Woodhouse, M., Linck, P., Suttie, A., Jackson, J., Lindsay, J., Wolffsohn, J., Hughes, L. and Margrain, T.H. (2012). How effective is low vision service provision? A systematic review. Survey of Ophthalmology, 57(1), pp. 34–65. doi:10.1016/j.survophthal.2011.06.006.
  16. Wood, A., Binns, A., Margrain, T., Drexler, W., Povaay, B., Esmaeelpour, M. and Sheen, N. (2011). Retinal and choroidal thickness in early age-related macular degeneration. American Journal of Ophthalmology, 152(6) . doi:10.1016/j.ajo.2011.05.021.
  17. Wood, A., Margrain, T. and Binns, A. (2011). The effect of bleach duration and age on the ERG photostress test. Graefe's Archive for Clinical and Experimental Ophthalmology, 249(9), pp. 1359–1365. doi:10.1007/s00417-011-1627-7.
  18. Gaffney, A.J., Binns, A.M. and Margrain, T.H. (2011). Topography of cone dark adaptation deficits in age-related maculopathy. Optom Vis Sci, 88(9), pp. 1080–1087. doi:10.1097/OPX.0b013e3182223697.
  19. Dickinson, C., Linck, P., Tudor-Edwards, R., Binns, A., Bunce, C., Harper, R., Jackson, J., Lindsay, J., Suttie, A., Wolffsohn, J., Woodhouse, M. and Margrain, T. (2011). A profile of low vision services in England: The low vision service model evaluation (LOVSME) project. Eye, 25(7), pp. 829–831. doi:10.1038/eye.2011.112.
  20. Gaffney, A.J., Binns, A.M. and Margrain, T.H. (2011). The repeatability of the Goldmann-Weekers adaptometer for measuring cone adaptation. Doc Ophthalmol, 122(2), pp. 71–75. doi:10.1007/s10633-011-9261-6.
  21. Binns, A.M., Mortlock, K.E. and North, R.V. (2011). The relationship between stimulus intensity and response amplitude for the photopic negative response of the flash electroretinogram. Doc Ophthalmol, 122(1), pp. 39–52. doi:10.1007/s10633-010-9257-7.
  22. Mortlock, K.E., Binns, A.M., Aldebasi, Y.H. and North, R.V. (2010). Inter-subject, inter-ocular and inter-session repeatability of the photopic negative response of the electroretinogram recorded using DTL and skin electrodes. Documenta Ophthalmologica, 121(2), pp. 123–134. doi:10.1007/s10633-010-9239-9.
  23. Tumlinson, A.R., Hermann, B., Hofer, B., Povazay, B., Margrain, T.H., Binns, A.M. and Drexler, W. (2009). Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomography. Jpn J Ophthalmol, 53(4), pp. 315–326. doi:10.1007/s10384-009-0684-5.
  24. Hermann, B., Torti, C., Fernández, E.J., Ahnelt, P., Považay, B., Hofer, B., Unterhuber, A., Binns, A., Margrain, T., Drexler, W., Unterhuber, A., Binns, A., Margrain, T. and Drexler, W. (2008). Towards in vivo imaging of photoreceptor morphology and function. Biomedical Optics, BIOMED 2008 .
  25. Binns, A.M. and Margrain, T.H. (2007). Evaluating retinal function in age-related maculopathy with the ERG photostress test. Invest Ophthalmol Vis Sci, 48(6), pp. 2806–2813. doi:10.1167/iovs.06-0392.
  26. Binns, A. and Margrain, T.H. (2006). Development of a technique for recording the focal rod ERG. Ophthalmic Physiol Opt, 26(1), pp. 71–79. doi:10.1111/j.1475-1313.2005.00355.x.
  27. Binns, A. and Margrain, T.H. (2005). Evaluation of retinal function using the Dynamic Focal Cone ERG. Ophthalmic Physiol Opt, 25(6), pp. 492–500. doi:10.1111/j.1475-1313.2005.00338.x.

Education

Modules taught on

- OV3019: Clinical Skills and Visual Impairment
- OV3017: Eye Disease and Therapeutics
- OV2004: Clinical Skills II
- OV1012: Clinical Skills
- OVM031: Primary Care

Other Activities

Editorial Activity

  1. Reviewer for:

    - Documenta Ophthalmologica
    - Acta Ophthalmologica
    - British Journal of Nutrition
    - Clinical and Experimental Optometry
    - Journal of Optometry
    .

Events/Conferences (2)

  1. European Low Vision Conference. Oxford University (2013).
    Description: The effectiveness of eccentric viewing training: a systematic review
  2. Macular Society Top Doctors Conference (Invited Speaker). (2013).
    Description: Research into a potential new treatment for early AMD. www.macularsociety.org/How-we-help/top-doctors

Find us

City, University of London

Northampton Square

London EC1V 0HB

United Kingdom

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City, University of London is an independent member institution of the University of London. Established by Royal Charter in 1836, the University of London consists of 18 independent member institutions with outstanding global reputations and several prestigious central academic bodies and activities.